Abstract
Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Type 1 diabetes is occurred most frequently in childhood and adolescence, although in recent years due to the increase in the prevalence of obesity in this category of population has been registered a growing number of cases of type 2 diabetes among children and adolescents (1, 2).
Highlights
Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health
The results of this study have shown that insulin resistance, quantified by eGDR, is more common in patients with diabetic retinopathy than in those without this complication
It showed that a low value of eGDR is independent associated with the presence of chronic complications of DM
Summary
Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Insulin resistance has been linked to the pathophysiology of type 2 diabetes mellitus (T2DM) and it has been proved to have an important role in the increase of the risk of cardiovascular complications [6,7,8,9,10,11,12]. Subsequent studies [18,19,20,21] showed a significant decrease in glucose disposal mediated by insulin among patients with T1DM suggesting the presence of insulin resistance. After a decade this combination has aroused the interest of many research studies [22-30] to investigate the possible mechanisms of insulin resistance in T1DM
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