Abstract
Autofluorescence of the cornea within specific wavelength region and dynamic light scattering measurements of ocular tissue have both been used for early-stage detection of the presence of diabetic retinopathy. In the present study, autofluorescence of the cornea and dynamic light scattering in the cornea and vitreous have been measured and compared using two innovative research instruments in twenty-two insulin-dependent diabetes mellitus patients, for the diagnosis of diabetic retinopathy. Corneal autofluorescence mean values in each diabetic retinopathy grade significantly correlated with dynamic light scattering measurements in the vitreous, and in the cornea, thus confirming that changes in the natural fluorescence is strictly correlated with molecular changes of ocular tissues. © 1998 Society of Photo-Optical Instrumentation Engineers.
Highlights
It is known that diabetic mellitus (DM) is associated with a number of biochemical alterations in the eye as well as in other organs
Corneal AF and the distribution of relaxation rate obtained by DLS measurements in the posterior vitreous and cornea were determined in insulin-dependent diabetes mellitus (IDDM) patients with three different grades of retinopathy, using systems designed for possible use in-vivo as screening instruments
The Gamma[max, vitreous] mean value of patients with background diabetic retinopathy (DR) were higher when compared to mean values obtained with patients with both negligible or proliferative DR
Summary
It is known that diabetic mellitus (DM) is associated with a number of biochemical alterations in the eye as well as in other organs. Such alterations are glycosylation of macroproteins and other metabolic disorders.[1,2,3,4] In general, the longer the DM duration, the more marked these alterations. Corneal AF and the distribution of relaxation rate obtained by DLS measurements in the posterior vitreous and cornea were determined in insulin-dependent diabetes mellitus (IDDM) patients with three different grades of retinopathy, using systems designed for possible use in-vivo as screening instruments.
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