Diabetic neuropathy and role of biochemical parameters in diabetic neuropathy

Abstract

Diabetic neuropathy (DN) is the most widely recognized and distressing microvascular manifestation of diabetes, prompting the best degree of morbidity and mortality and bringing about an enormous financial weight for diabetes care. One of the major causesin DN is uncontrolled diabetes or hyperglycemia followed by nerve damage. The severity of DN is primarily associated with age, sex, plasma glucose level, hemoglobin A1C(HbA1C)value, length ofdiabetes, and Body Mass Index (BMI). The clinical assessment of peripheral neuropathy and its alternative treatments are multifactorial. The angiogenic proteinvascular endothelialgrowthfactor (VEGF) contributes a significant role in DN. Thus this review article presents knowledge about the different perspective soft hedisease, incidence epidemiology, pathophysiology, and the organ which are affected, diagnosis, prognosis followed by management of DN. The early diagnosis of diabetic neuropathies may help to reduce the severity of the disease as well the biochemical parameters involved in diabetic neuropathy can give a clear picture about the patient physical as well as the neurological status and protein like VEGF estimation can be used as a good predictor of Diabetic neuropathy.