Abstract
Sciatic nerves from 21 alloxan diabetic male albino rats and 6 control animals have been studied histopathologically after 4–6 months' hyperglycemia. Nine of the diabetic animals were uncontrolled, while the remaining 12 rats received 2.5 U insulin daily. Both groups showed a mild degree of myelin degeneration at 4 months, but at 5 and 6 months the uncontrolled diabetic group developed a significantly more severe degree of myelin and axis-cylinder degeneration than the insulin-treated group. The intraneural blood vessels were essentially normal in all animals. The role of duration and severity of hyperglycemia, with particular reference to the protective effect of early insulin therapy on nerve lesions, is discussed.
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