Abstract
To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes. There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR. The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.
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