Abstract
Children and adolescents who present in ketoacidosis at manifestation of the disease might represent a subgroup of patients that may have less resilience factors in their families, less adherence to medical advice, might be less attentive to medical symptoms and might be less knowledgeable of medical issues. In addition, they may carry biologic risk factors - be it either genetic or exogenous - that lead to a more severe onset and more dramatic course of the disease. Lastly, less endogenous insulin reserve may be present in patients who enter ketoacidosis than in those who remain in a somewhat more stable metabolic condition during manifestation.
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