Abstract
Hyperadrenocorticism (HAC) is insulin antagonistic that can interfere with insulin therapy. It is a common cause of insulin resistance in diabetic dogs. Eleven poorly regulated diabetic dogs (mean age: 9.4±3.2 years) with concurrent HAC were studied. Nine of them (9/11) were females. Predominant clinical findings included: polyphagia (11/11). polydipsia (10/11), polyuria (10/11), cutaneous manifestations (9/11), gastrointestinal upsets (9/11), bilateral cataracts (8/11) and weight loss (8/11). Persistent fasting hyperglycemia (11/11), glycosuria (11/11), elevated ALKP (10/11), hyponatremia (10/11), lipemia (9/11), hypochloremia (9/11) and ketonuria (8/11) were the most consistent findings in laboratory tests. 8ased on results of adrenocorticotropic hormone stimulation tests and medical images, 6 were pituitary-dependent HAC, 1 had adrenal tumor, 4 were iatrogenic HAC. In 7 dogs with spontaneous HAC, 4 had good diabetic regulation after HAC was managed. Three dogs with iatrogenic HAC also showed good diabetic regulation after remiss ion of iatrogenic HAC was completed.
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