Abstract
The results of epidemiological and several interventional studies suggest an association between vitamin D deficiency and an increased risk of developing insulin resistance or type 2 diabetes. Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D < 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas. A recent study by Pittas et al. did not show a clear preventive effect of vitamin D supplementation with respect to the risk of developing type 2 diabetes. In terms of this study, it must be remembered that more than 70% of the participants in both the vitamin D supplement group and the placebo group did not have a vitamin D deficiency. In medical and pharmaceutical practice, more attention should be paid to vitamin D deficiency than has previously been accorded. Vitamin D status can be assessed objectively when necessary by laboratory testing of the serum 25(OH)D levels. Type 2 diabetes patients benefit from improving their vitamin D status with respect to their glucose metabolism and decreased mortality risk. Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40–60 ng/mL.
Highlights
According to WHO data, the prevalence of type 2 diabetes almost doubled worldwide between1980 and 2014, with an estimated 422 million people suffering from diabetes mellitus in 2014 [1,2].Obesity, type 2 diabetes, and vitamin D deficiency are pandemic diseases of our time, affecting millions of people throughout the world
The results of this study showed that the benefits of vitamin D supplementation for improving insulin resistance depended on the baseline 25(OH)D status
The results of studies from Australia and Sweden substantiate the evidence for an association between vitamin D deficiency and the risk of metabolic syndrome or the progression from prediabetes to manifest type 2 diabetes
Summary
According to WHO data, the prevalence of type 2 diabetes almost doubled worldwide between. 1980 and 2014, with an estimated 422 million people suffering from diabetes mellitus in 2014 [1,2]. Type 2 diabetes, and vitamin D deficiency are pandemic diseases of our time, affecting millions of people throughout the world. The results of the latest epidemiological studies, interventional studies, and meta-analyses suggest an association between vitamin D deficiency and an increased risk of developing insulin resistance or type 2 diabetes. There have been contradictory results from previous studies that do not focus on vitamin D deficient states. In this commentary, we reflect on how these findings can be explained [3,4,5,6,7]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.