Abstract
Early membranous nephropathy with diabetes mellitus is often easily misdiagnosed as diabetic nephropathy. Tacrolimus is a common drug for the treatment of membranous nephropathy, and CYP3A5 gene plays an important role in its metabolism. The decreased expression activity of CYP3A5 gene leads to the increased blood concentration of tacrolimus and adverse reactions. We report the case of diabetes mellitus with early membranous nephropathy and H.pylori infection in a 55-year-old female. Our patient was diagnosed with membranous nephropathy by renal puncture. Due to the slow metabolism of CYP3A5, tacrolimus was reduced to avoid side effects. After eradication of H.pylori, the patient’s urine protein decreased and the prognosis of membranous nephropathy was good. There was no discomfort during the follow-up period after the patient was discharged.
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