Diabetes Mellitus Type 2 and role of GINSENG as a Prevention and Control.

Abstract

Introduction: Diabetes is one of the most challenging diseases of this era. Improper dietary habits and sedentary life style are considered as the foundation stone for metabolic disorders including diabetes. Intake of large amount of animal fat leads to insulin resistance (IR) and oxygen radical formation.IR leads to increase glucose level in blood resulting in diabetes mellitus.Objectives: This experimental study was intended to correlate high fat diet re-sulting in weight gain to diabetes and emphasized the role of ginsenoside in reduc-ing body weight and blood glucose level by both increasing insulin secretion as well as increasing the sensitivity of insulin receptors.Methodology: This is an experiment study on animal model, conducted at DUHS during the year 2017. It comprises of 50 male Albino Wister rats. They were divided into 5 groups for study purpose. Group1 was put on normal balanced diet and serve as control, while other 4 groups were treated with different diet. The ani-mals were sacrificed after 12 weeks; blood sugar was monitored weekly for 12 weeks and finally at the end of experiment, there blood sugar level were estimated. Statistical analysis was done by using SPSS 16, using ANOVA test to evaluate the significance among groups. P-Value < 0.05 was considered as significant.Results: The collected data was interpreted as Mean ± S.D. The results revealed that high fat diet increases blood glucose level, remarkably increase body weight as well as liver weight. By the administration of ginseng root extract significant de-crease in body weight, liver weight and blood glucose levels was observed in dose dependent manner.Conclusion: The results of this study revealed that high fat diet (HFD) is a major cause of metabolic syndrome including diabetes. It can be prevented by changing life style and introducing ginseng as anti-diabetic agent in obese.Key Words: Diabetic mellitus, body weight, Ginsenoside