Abstract
Diabetes mellitus type 2 and depressive symptoms are statistically associated. The question is if one of the two diseases is causal for the other. Systematic review using Medline and searching for prospective controlled population based observational studies and meta-analysis in English or German language. Patients with type 2 diabetes have a higher incidence of depressive symptoms - compared to patients having no diabetes. And patients with depressive symptoms have a higher incidence of type 2 diabetes; however the findings for the first relation are only weak. Knowing about this - even causal - co-morbidity is important in care, including a routine diagnostic approach to find out if the other disease is also present.
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