Abstract
BackgroundHemodialysis is essential for the survival of patients suffering from chronic renal failure. However, in diabetics the incidence of dry eye disease is higher than in non-diabetic individuals. Accordingly, we evaluated if this difference is attributable to different effects of hemodialysis on basal tear fluid secretion.MethodsA modified Schirmer´s eye test determined if hemodialysis improved basal tear secretion rates in 36 diabetic and non-diabetic patients undergoing hemodialysis.ResultsBasal tear secretion was invariant in diabetic patients whereas in non-diabetic individuals this process increased.ConclusionIn non-diabetic patients, autonomic neuropathy appears to be less severe and somewhat reversible since only in these individuals hemodialysis improved basal tear fluid secretion. This difference may be a factor contributing to the lower incidence of dry eye disease in non-diabetic patients.
Highlights
Hemodialysis is essential for the survival of patients suffering from chronic renal failure
Among patients in another study undergoing hemodialysis for chronic renal failure, the incidence of reduced basal tear secretion and dry eye symptomology is higher in diabetic patients than in non-diabetics [17]
There were no significant differences in serum creatinine level, dehydration volume, or duration of hemodialysis treatment between the diabetic and non-diabetic groups
Summary
Hemodialysis is essential for the survival of patients suffering from chronic renal failure. In diabetics the incidence of dry eye disease is higher than in non-diabetic individuals. Methods: A modified Schirmers eye test determined if hemodialysis improved basal tear secretion rates in 36 diabetic and non-diabetic patients undergoing hemodialysis. Conclusion: In non-diabetic patients, autonomic neuropathy appears to be less severe and somewhat reversible since only in these individuals hemodialysis improved basal tear fluid secretion. This difference may be a factor contributing to the lower incidence of dry eye disease in non-diabetic patients. Among patients in another study undergoing hemodialysis for chronic renal failure, the incidence of reduced basal tear secretion and dry eye symptomology is higher in diabetic patients than in non-diabetics [17]. Even though the incidence of dry eyes is higher in diabetic
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