Abstract
Trigger finger (TF) or stenosing tenosynovitis has been associated with diabetes mellitus (DM), although today's knowledge is mostly based on cross-sectional and case-control studies. Thus, the aim of the present population-based cohort study over more than 20 years was to investigate DM as a risk factor for TF. Data from Malmö Diet and Cancer Study (MDCS), including 30,446 individuals, were analysed with regards to baseline DM and known or potential confounders. Information regarding TF diagnosis until study end date of Dec 31st, 2018, was retrieved from the Swedish National Patient Register (NPR) using ICD-codes. Survival probability was investigated in Kaplan-Meier plots. Cox proportional hazard regression model was used to evaluate DM as risk factor for TF, adjusted for several confounders and presented as Hazard Ratio (HR) with 95% confidence intervals (CI). At baseline, 4.6% (1,393/30,357) participants had DM. In total, 3.2% (974/30,357) participants were diagnosed with TF during the study period. Kaplan-Meier plot showed that the probability for incident TF was significantly higher in participants with baseline DM compared with individuals without baseline DM. Adjusted HR for DM as risk factor for TF was 2.0 (95% CI: 1.5-2.6, p<0.001). This longitudinal study showed that DM is an important risk factor for developing TF. When adjusting for sex, age, BMI, manual work, statin use, smoking and alcohol consumption, DM remained the main risk factor for TF.
Highlights
Diabetes Mellitus (DM) is one of modern time’s most challenging long-term public health challenges, both in terms of individual suffering and health care economics
The same was applied for participants who were already diagnosed with trigger finger (TF) (n=31) when they were recruited to the Malmö Diet and Cancer study (MDCS) (Figure 1)
Baseline DM resulted in increased hazard ratio (HR) in the univariate Cox proportional hazard (PH) regression model (HR 2.27; 95% confidence interval (CI): 1.8-2.87; p
Summary
Diabetes Mellitus (DM) is one of modern time’s most challenging long-term public health challenges, both in terms of individual suffering and health care economics. Trigger finger (TF), known as stenosing tenosynovitis, tenovaginitis or digitus saltans, is a condition where the flexor tendon is obstructed in its tendon sheath at the first annular (A1) pulley. This results in a locking phenomenon, and the affected finger can only be extended with additional force or passive manipulation, which can be painful. Trigger finger (TF) or stenosing tenosynovitis has been associated with diabetes mellitus (DM), today’s knowledge is mostly based on crosssectional and case-control studies. The aim of the present population-based cohort study over more than 20 years was to investigate DM as a risk factor for TF
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