Abstract
Three teenagers with well-controlled epilepsy who developed drug refractory partial seizures correlated with nonketotic hyperglycemia and insulin-dependent diabetes mellitus are reported from the Children’s Hospital of Eastern Ontario, University of Ottawa, and Children’s Hospital, Dalhousie University, Halifax, Nova Scotia, Canada.
Highlights
PERINATAL IV ALUMINUM AND DEVELOPMENTAL DELAYThe 90 infants who received standard IV feeding solutions, containing 25 meg Al/dl, had a lower Bayley Mental Development Index at 18 months than the 92 infants who received aluminumdepleted solutions (2.2 meg Al/dl)
The majority of cases of aluminum poisoning occur as dialysis encephalopathy in adult patients on hemodialysis and peritoneal dialysis
Three teenagers with well-controlled epilepsy who developed drug refractory partial seizures correlated with nonketotic hyperglycemia and insulin-dependent diabetes mellitus are reported from the Children's Hospital of Eastern Ontario, University of Ottawa, and Children's Hospital, Dalhousie University, Halifax, Nova Scotia, Canada
Summary
The 90 infants who received standard IV feeding solutions, containing 25 meg Al/dl, had a lower Bayley Mental Development Index at 18 months than the 92 infants who received aluminumdepleted solutions (2.2 meg Al/dl). Aluminum exposure (45 mcg/kg/day) caused a mean loss on the Bayley Index of 1 point per day. Infants receiving standard IV solutions for 10 or more days had a 10 point deficit in their Mental Development Index and were twice as likely to have an index below 85. Aluminum neurotoxicity in preterm infants receiving intravenous feeding solutions. Aluminum exposure from standard intravenous solutions in preterm infants may cause neurotoxicity and developmental delay at 18 months. Especially when treated with aluminum sulfate to remove organic contaminants, contains high concentrations of aluminum and is a frequent cause of dementia following repeated dialyses.
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