Abstract
It has been shown that diabetic patients have bone fragility independent of bone mineral density. Recently, diabetes-related bone disease is recognized as one of diabetic complications. It is reported that advanced glycation end products(AGEs)collagen cross-links, low bone turnover with osteoblastic dysfunction, and abnormality of microarchitectures such as cortical porosity and deterioration of trabecular bone structure are involved in diabetes-related bone disease. AGEs and homocysteine directly and negatively affect osteoblasts and osteocytes. Moreover, anti-diabetic drugs also affect bone metabolism. Therefore, the underlying mechanisms are very complex. In this review, we describe the effects of diabetes on bone metabolism based on the recent evidence.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
