Abstract
Abstract Objectives: To investigate the effects of diabetes on the reproductive system andextracellular matrix proteins of diabetic rats. Materials and Methods: Wistar albinomale rats, body weight (BW) 160-200 g, were divided into two groups: I -streptozoticin diabetes, II - normal non-diabetic animals. The content of amino acidsin rat type I collagen was determined using an amino acid analyzer. Morphologicalanalyses of gonadic structures were carried out by an optic microscope. Results: Thestudy of the effects of diabetes on type I collagen amino acid content, testis cellsmorphologic and morphometric parameters and spermatogenesis demonstrated thepresence of diabetes-mediated quantitative and qualitative changes in male ratreproductive organs, spermatogenetic epithelial cells and extracellular matrixproteins in comparison with normal. Conclusions: Observed collagen moleculeschanges could hence affect the properties and correct functioning of spermatogeneticepithelium and of other tissues of reproductive organs. They could be caused bydiabetes via deficiency of insulin which is involved in collagen synthesis regulationat different stages of this process, cytochrome P450-2E1 induction and reactiveoxygen species effects on protein biosynthesis processes.
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