Abstract
Objectives: We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods: We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors. Results: Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m2. Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (p < 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05–1.83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI. Conclusions: Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis.
Highlights
Osteoporosis and fragility fractures represent a growing health problem in developed countries in terms of social costs and increased risk of death, especially in the elderly [1]
We present the updated analyses of the ROIS/EMEROS registry focusing on the association between some major clinical conditions and bone demineralization in a population living in a specific area characterized by heavy environmental pressure between Brindisi and Taranto
Before the kick-off of the project, ISBEM researchers developed a questionnaire in order to record main clinical information of each patient; the questionnaire includes all the mandatory fields and items of the electronic form developed by the Italian Society of Osteoporosis of Bone Mineral and of Skeletal Disease (SIOMMMS)
Summary
Osteoporosis and fragility fractures represent a growing health problem in developed countries in terms of social costs and increased risk of death, especially in the elderly [1]. Fracture incidence rates are closely related to the ageing of a population, as older people present higher fracture rates than younger subjects with the same bone mineral density [2]. This is due to a lower bone quality and higher tendency to fall. According to the ESOPO (Epidemiological Study on the Prevalence Osteoporosis in Italy) study, about 5 million Italians suffer from osteoporosis with almost 1.5 million of these subjects being “at high risk” of femoral fracture because they have already experienced one or more vertebral fractures [4]. Hospital costs of femoral fractures in the elderly Italian population account for 1 billion
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