Diabetes and Cardiovascular Effects of Air Pollution

Abstract

P-050 Introduction: the effects of air pollution and cardiovascular diseases (CVD) have been studied in several cities. Previous studies have reported the risk increase in diabetics when compared to non-diabetic groups. This study was conducted to estimate the effect modification of air pollution effects on CVD induced by diabetes. Methods: This study carried out from 2001 to 2004 and we adopted generalized linear Poisson regression models to assess the effects of PM10, CO, NO2, SO2, and O3 on CVD on diabetic and non-diabetic groups controlling for seasonality (long and short-term trends) and weather variables using a semi-parametric smoother (spline). The 2 days cumulative effects of air pollutants were assessed using 2 day moving average. Results: PM10 was not associated with cardiovascular diseases in any group. An interquartile range increase on SO2 concentration (8.0 μg/m3) was associated with increases of 6.0% (95% CI: 4.0–8.0) and 17.0% (95% CI: −1.0–34.0) on CVD admissions for non-diabetic and diabetic groups, respectively. Conclusion: This study showed that air pollution has a remarkable impact on cardiovascular morbidity, mainly in a high susceptible group like the diabetic population, reinforcing the necessity of additional studies to confirm these finds. This study was funded by: UNISANTOS, and CEACL-UNIFESP.