Abstract
Importance: Neovascular glaucoma (NVG) is a severe form of secondary glaucoma has a varying prevalence of 0.01 to 3.9% of all glaucoma in different regions of world. Majority of them are affected with proliferative diabetic retinopathy. Although NVG overall prevalence is low but it is a dreadful condition led to blindness. If not detected earlier of the disease by latest investigating majors and treated systematically on different stages of the disease along with taking care of the alleviation of different aggravating factors for retinal hypoxia. Objectives: To summarize published evidence on etiopathogenesis, clinical feature, stages of NVG and to provide treatment recommendation on different stages of the NVG for ophthalmologists based on published evidence. Evidence Review: A literature search of PubMed was conducted from January 1, 1974 to June 30, 2022. Publications describing prevalence, etiopathogenesis, clinical staging, investigation and treatment modality were included in the study. Findings: NVG is characterized by development of new vessels on iris and fibrovascular tissue proliferation in the anterior chamber angle with increase in IOP, principally driven by Retinal ischemia and among the commonest causes are proliferative diabetic neuropathy (PDR), central retinal venous occlusion, and ocular ischemic syndrome (OIS).
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