Abstract
Materials and methods Eighteen healthy female subjects participated in this PET study. The selective 5-HT1A receptor antagonist [carbonyl-11C]WAY-100635 was used as radioligand. The hypothalamus as an essential part of the HPA axis and eight control regions of interest and the cerebellum as reference region were defined a priori and delineated on coregistered MR images. DHEAS and cortisol plasma levels were ascertained by morning blood collections on the PET day. The 5-HT1A receptor binding potentials of the target brain regions were correlated with DHEAS, cortisol plasma levels and the ratio of DHEAS / cortisol.
Highlights
Serotonin modulates the activity of the hypothalamicpituitary-adrenal (HPA) axis, to a big part through the serotonin-1A receptor (5-HT1A) [1]
The 5-HT1A receptor binding potentials of the target brain regions were correlated with dehydroepiandrosterone sulfate (DHEAS), cortisol plasma levels and the ratio of DHEAS / cortisol
We found highly significant correlations between the hypothalamic 5-HT1A receptor binding and DHEAS (p=.003) and the ratio of DHEAS / cortisol (p
Summary
Serotonin modulates the activity of the hypothalamicpituitary-adrenal (HPA) axis, to a big part through the serotonin-1A receptor (5-HT1A) [1]. DHEAS and cortisol correlate with Hypothalamic Serotonin-1A Ulrike Moser*1, Wolfgang Wadsak2, Patrycja Stein1, Christoph Spindelegger1, Markus Mitterhauser2,3, Alexander Holik1, Christian Bieglmayer4, Kurt Kletter2, Siegfried Kasper1 and Rupert Lanzenberger1
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
