Abstract
Accumulating evidence illustrates the beneficial effects of dietary docosahexaenoic acid (DHA) on cardiovascular diseases. However, its effects on cardiac arrest (CA) remain controversial in epidemiological studies and have not been reported in controlled animal studies. Here, we examined whether dietary DHA can improve survival, the most important endpoint in CA. Male Sprague-Dawley rats were randomized into two groups and received either a control diet or a DHA-supplemented diet for 7–8 weeks. Rats were then subjected to 20 min asphyxia-induced cardiac arrest followed by 30 min cardiopulmonary bypass resuscitation. Rat survival was monitored for additional 3.5 h following resuscitation. In the control group, 1 of 9 rats survived for 4 h, whereas 6 of 9 rats survived in the DHA-treated group. Surviving rats in the DHA-treated group displayed moderately improved hemodynamics compared to rats in the control group 1 h after the start of resuscitation. Rats in the control group showed no sign of brain function whereas rats in the DHA-treated group had recurrent seizures and spontaneous respiration, suggesting dietary DHA also protects the brain. Overall, our study shows that dietary DHA significantly improves rat survival following 20 min of severe CA.
Highlights
Accumulating evidence illustrates the beneficial effects of dietary docosahexaenoic acid (DHA) on cardiovascular diseases
Docosahexaenoic acid (DHA)-supplemented diet had no significant effect on hemodynamics as pulse pressure (PP), mean arterial pressure (MAP), and systolic pressure (SP) were similar between the two groups
We have demonstrated that rats on a DHA-enriched diet have a significantly higher survival rate following 20 min Cardiac arrest (CA) compared to rats on a standard diet
Summary
Accumulating evidence illustrates the beneficial effects of dietary docosahexaenoic acid (DHA) on cardiovascular diseases. Various controlled resuscitation methods have been tested in animal models and in clinical applications[5,6]. Controlled animal studies have provided evidence that dietary DHA protects organs from ischemic damage. Whether the prevention of these biochemical and cellular responses in isolated ischemic organs can improve the function of organs in whole-body ischemia is still questionable Whether this protection can be further extended to the survival of animals after CA has not been examined. We tested whether dietary DHA is protective against CA using a rat model of asphyxia-induced CA followed by cardiopulmonary bypass (CPB) resuscitation. CPB resuscitation, a newly developed resuscitation method for human patients who do not respond to conventional cardiopulmonary resuscitation[5,27,28,29], provides relatively consistent blood flow to individual organs compared to conventional CPR, reliably resuscitates animals following prolonged CA24
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