Abstract
Equine pancreatitis has no reliable ante-mortem test and is considered rare. The 1,2-o-dilauryl-rac-glycero-3-glutarate-(6′-methylresorufin) ester (DGGR) lipase assay is specific for pancreatic lipase (PL). It was developed for humans and validated in dogs, cats and rats as specific for pancreatitis diagnosis. We used a novel validation strategy to confirm this tissue specificity extended to horses and determine reference ranges and pancreatitis prevalence. One hundred thirty-nine horses were used. Biopsies were collected from 3 healthy cadavers and venous blood from 109 clinical cases and 27 training racehorses. DGGR-lipase was demonstrated to only occur significantly in the pancreas using 7 different tissues collected at euthanasia that were cryopreserved and assayed for PL and 6, other, routine biomarkers (amylase, CK, GLD, AST, ALT, ALP). PL range was determined in healthy horses and in pancreatitis cases. PL is an inexpensive, highly-effective biomarker with the highest tissue activity and specificity of routine biomarkers. Equine pancreatitis occurs with a high prevalence and severity similar to that in dogs and cats, and in association with a wide variety of gastrointestinal disorders and with training racehorses. PL should be routinely assayed in horses with gastrointestinal disorders and monitored in training racehorses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
