Abstract
A medication combining dextromethorphan and bupropion was more efficacious than an active comparator and placebo in reducing depressive symptoms in adults with major depressive disorder, a pair of trials has found. Remission rates with dextromethorphan‐bupropion separated from the comparator and placebo by week 2 of treatment in each study, according to researchers. Results of the Phase 2 trial of the medication were published online May 18 in the American Journal of Psychiatry, and results of the Phase 3 trial were published online May 30 in the Journal of Clinical Psychiatry.
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