Dextran-polyethylene glycol cryogels as spongy scaffolds for drug delivery

Abstract

Cryogels are a particular type of hydrogels that possess great potential in both fields of drug delivery and tissue engineering. Based on these premises, the goal of this work was to develop a cytocompatible polymeric cryogel, which could be used as a spongy scaffold to promote the delivery of biomolecules. Precisely, the novel formulation was fabricated by combining dextran methacrylate (DEX-MA) and polyethylene glycol dimethacrylate (PEG-DMA) through radical polymerization at a temperature of −15 °C. The swelling, porosity, mechanical properties, and the drug release profile of vitamin B12 from the optimized cryogel were evaluated and compared to hydrogels fabricated at room temperature. The use of the cryo-gelation technique enabled the formation of scaffolds with improved swelling, increased interconnected porosity, and higher mechanical resistance than conventional hydrogels. The cryogels proved to be non-toxic and suitable carriers for the delivery of water-soluble biomolecules. Overall, the novel cytocompatible cryogel formulation could be used for biomedical applications that require the need of a macroporous scaffold for localized delivery of bioactive molecules.