Abstract
The attractiveness of the dextran nanoparticle application in medicine and pharmacology results from biocompatibility, biodegradability, and nontoxicity of the polymer. However, it still remains a challenge to prepare such nanoparticles in an aqueous medium due to dextran hydrophilicity. Here, the technique of dextran nanoparticle synthesis with the average diameter of 140–450 nm in aqueous and aqueous/ethanolic media is described. The chemical structure of cross‐linker used for the dextran nanoparticle stabilization is demonstrated to influence the dextran nanoparticle diameter, size distribution, and ζ‐potential. As shown the regulation of the nanoparticle diameter and ζ‐potential is possible through the surfactants and/or dextran nonsolvent (ethanol) addition into the reaction medium. Due to the additional steric stabilization, the dextran nanoparticles of minimum diameter are formed in the presence of ionic surfactants in the aqueous/ethanolic medium. The nanoparticle shape and diameter are analyzed by dynamic light scattering, transmission electron microscopy, and scanning electron microscopy; the composition is investigated by 1H NMR spectroscopy. image
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