Abstract
BackgroundThis study was designed to evaluate the effects of infusion of magnesium sulfate compared to dexmedetomidine on the postoperative analgesic consumption and pain control in patients scheduled for video-assisted thoracoscopic surgeries (VATS). The intraoperative hemodynamics, anesthesia requirements, and recovery profile were also evaluated.ResultsThe mean arterial pressure (MAP) and heart rate (HR) recordings were significantly lower in group D than in groups C and M. The MAP recordings were significantly lower in group M than in group C with no significant difference as regards the HR recordings between both groups. Intraoperative sevoflurane and fentanyl requirements were significantly lower in groups D and M than in group C and in group D than in group M. The atracurium consumption was significantly lower in group M than in groups C and D. The time to reach modified Aldrete score ≥ 9 was significantly longer in groups D and M than in group C and in group D than in group M. Postoperative Ramsay sedation scores were significantly higher in groups D and M than in group C throughout the PACU stay and in group D than in group M in the 1st h postoperatively. The VAS score recordings were significantly lower in groups D and M than in group C and in group D than in group M except at 24-h postoperative recordings. The postoperative nalbuphine and ketorolac requirements were significantly lower in groups D and M than in group C and in group D than in group M.ConclusionsDuring VATS, patients who received dexmedetomidine had better hemodynamic stability, less intraoperative anesthetic consumption with better quality of postoperative analgesia, and less postoperative analgesic consumption but longer postoperative anesthesia recovery and higher postoperative sedation scores compared with magnesium sulfate.
Highlights
This study was designed to evaluate the effects of infusion of magnesium sulfate compared to dexmedetomidine on the postoperative analgesic consumption and pain control in patients scheduled for videoassisted thoracoscopic surgeries (VATS)
Among 106 patients that were scheduled to undergo VATS and screened to be eligible for this study, sixteen patients were excluded as four patients refused to participate and twelve patients did not meet this study’s inclusion criteria; 90 patients were included in this study and randomized to either the magnesium group, dexmedetomidine group, or control group (30 patients per group) (Fig. 1)
In group C, there was a significant increase in mean arterial pressure (MAP) at T2 recordings compared to T0 (P < 0.05) with no significant difference at all other recordings compared to T0 (P > 0.05)
Summary
This study was designed to evaluate the effects of infusion of magnesium sulfate compared to dexmedetomidine on the postoperative analgesic consumption and pain control in patients scheduled for videoassisted thoracoscopic surgeries (VATS). Magnesium acts as an N-methyl-D-aspartate (NMDA) receptor antagonist; it reduces perioperative analgesic and anesthetic requirements (Srebro et al, 2017). It was employed as the hypotensive agent in diverse surgical procedures for several years (Elsharnouby & Elsharnouby, 2006). This study aimed to compare the effects of magnesium sulfate compared to dexmedetomidine infusion on the postoperative analgesic consumption and pain control in patients who underwent VATS. The intraoperative hemodynamics, anesthesia requirements, and recovery profile were evaluated
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