Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: A case-control study

Abstract

ObjectiveTo evaluate the efficacy and safety of dexmedetomidine for emergence agitation after tonsillectomy in children. Methods120 ASA physical status I and II children, aged 5–14 years, undergoing anesthesia for tonsillectomy, were randomly divided into 3 groups: Placebo group, the low dexmedetomidine concentration group and the high dexmedetomidine concentration group. Before the entrance of the operating room (OR), all of the children received intravenous injection 40μgkg−1 midazolam to reduce anxiety at first, and then dexmedetomidine was given intravenously at an initial loading dose of 0.5μgkg−1 or 1μg/kg over a 10-min period via a computer controlled infusion pump followed by a maintenance infusion of 0.2μgkg−1h−1 or 0.4μgkg−1h−1over the surgery. The heart rate, SpO2 and mean arterial blood pressure were recorded for each patient in both operation room and PACU. The designated time points: at the start of the anesthetic induction, at the discontinuation of inhalational agents, at first opening of eyes, at time to remove endotracheal tube were recorded. After patient arrival at the PACU, VAS score, RSS, the occurrence of emergence agitation were recorded every 5min for the first 30min and every 10min for the next 30min after endotracheal tube was removed. ResultsThere was significant difference in the incidence of emergence agitation between Placebo group and the high concentration group when endotracheal tube was removed (P<0.05). There was significant difference in the VAS pain scores and in the RSS between three groups at the time of extubation, as well as 5min and 10min after extubation (P<0.05). ConclusionsDexmedetomidine appears to be safe and effective to reduce the incidence of early emergence agitation in children after tonsillectomy. Initial loading dose of 1.0μgkg−1 followed by a maintenance infusion of 0.4μgkg−1h−1 is better choice for children received tonsillectomy.