Dexmedetomidine infusion for prevention of emergence agitation from anesthesia in pediatric ophthalmic surgery

Abstract

Objective To investigate the security and effectiveness of dexmedetomidine infusion for prevention of emergence agitation from intravenous anesthesia in ophthahmic surgery.Methods 60 operations of pediatric ocular trauma were randomly divided into two groups:The dexmedetomidine group (group A,n =30) and the control group(group B,n =30)).When anesthesia induction was administrated,normal saline 20 ml or dexmedetomidine 0.5 μg/kg diluted to 20 ml was intravenously infused in 10 minutes.The difference between the mean artery pressure(MAP),heart rate(HR) and SpO2 before injection(T0),5 minutes after injection(T1),awakening(T2),5 minutes after extubation(T3),10 minutes after extubation (T4) and the agitation scale were observed in two groups.Results There was no significant difference between the two groups in sex,age,weight,time of operation and SpO2 in T0 to T4 (x2 =0.082,t =0.398,0.296,0.765,P ＞0.05).Compared with group B,the HR of T1,the MAP,HR and agitation scale of T2,T3 and T4 were lower in group A (t =5.651,12.438,10.928,14.247,13.819,17.717,15.141,2.321,8.797,8.797,x2 =5.963,8.365,6.667,P ＜ 0.05) in two groups.Conclusion Dexmedetomidine of 0.5 μg/kg was intravenously infused 10 min before anesthesia induction can safely and effectively reduce the occurrence of emergence agitation from anesthesia in pediatric ophthalmic surgery. Key words: Dexmedetomidine ; Surgery, ophthalmic, pediatric ; Anesthesia, intravenous ; Agitation, emergence