Abstract
BackgroundIn this study, the individual and combined inhibitory effects of dexmedetomidine and lidocaine on the conduction group of isolated nerve were investigated by determining conduction velocity distribution (CVD) and power spectrum.MethodsElectrophysiological compound action potential (CAP) recordings were conducted on isolated rat sciatic nerve before (Con) and 20 minutes after exposure to 1 mM lidocaine (Lido), 21pM dexmedetomidine (Dex) and their combination (Lido + Dex). Then for CVD, mathematical model and for power spectrum Fast Fourier analysis were conducted.ResultsDexmedetomidine alone made no significant difference in shape and duration of CAPs as compared to Con, on the other hand lidocaine depresses amplitude and prolongs the duration of CAPs, but not more than combination of dexmedetomidine and lidocaine can do.Lidocaine caused a shift in the CVD histogram to relatively slower conducting group significantly while dexmedetomidine did not cause any significant change as compared to Control. Lidocaine, when combined with dexmedetomidine revealed a remarkable effect on the whole CVD histogram by causing almost complete blockage of fast conducting nerve fibers. The relative number of fibers in CVD is conserved for separate applications of anesthetics, but not for their combination.As in CVD, power spectrum shifted from higher to lower frequency region by lidocaine and significantly for lidocaine combined with dexmedetomidine application. Shifts for dexmedetomidine applied group were seen beggarly.ConclusionsWe have concluded that dexmedetomidine alone did not influence nerve conduction, but when it is used with lidocaine it augments neural conduction blockage effect, especially on fast conducting nerve fibers.
Highlights
In this study, the individual and combined inhibitory effects of dexmedetomidine and lidocaine on the conduction group of isolated nerve were investigated by determining conduction velocity distribution (CVD) and power spectrum
This study aims to investigate the comparative inhibitory effect of dexmedetomidine and lidocaine on conduction velocity group of isolated nerve by determining CVD and power spectrum
We have observed that treating the rat sciatic nerve with lidocaine depresses the associated compound action potential (CAP) more as compared with dexmedetomidine
Summary
The individual and combined inhibitory effects of dexmedetomidine and lidocaine on the conduction group of isolated nerve were investigated by determining conduction velocity distribution (CVD) and power spectrum. Investigation on molecular mechanism by which local anesthetics alter specific function of peripheral nerve system implicates the sodium (Na+) channels. It can affect potassium (K+) and calcium (Ca2+) channels [1]. By binding to the presynaptic α2-adrenoceptors, it inhibits the release of norepinephrine, terminate the propagation of pain signals [3]. It is used for anesthetic-sparing effects and analgesia [4]. It can affect transcarinal motor evoked responses, [5,6] yet there are limited reports regarding its ionic mechanism of action on neurons
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