Background: In patients who undergo general anesthesia, the need for intubation and laryngoscopy is paramount. There will be hemodynamic changes in the body which occur due to intubation ultimately leading to stress. Aim: The aim of the study was to compare the efficacy of dexmedetomidine 1 μg/kg and magnesium sulfate 30 mg/kg in reducing the stress response occurring due to intubation and laryngoscopy. Methods: A randomized and double-blinded study was carried out in 60 participants who were divided into two groups. Group D were given dexmedetomidine 1 μg/kg while Group M were given magnesium sulfate 30 mg/kg. The baseline vitals were monitored at 0, 1, 3, 5, and 10 minutes after intubation. Results: The heart rate and blood pressure showed an increase in both the groups after intubation. However, the pre-induction values were reached earlier in the Group D when compared to the Group M patients. Conclusion: The patients who were pre-induced with dexmedetomidine 1 μg/kg showed a better hemodynamic stability when compared to those given magnesium sulfate 30 mg/kg.

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