Abstract
Nerves and blood vessels are completely different original tissue types and have distinct patterns in development and discrete features in anatomy and cellular biology. Stroke is a group of vascular diseases occurred in brain. Currently no reports show effective treatments restoring the blood vessels after injury in centre nerve system (CNS). Backed by my 20 years medical research experiences, I hypothesis that the lateral circulation could be induced through neovascularization by employing hormone at the sub acute stage of stroke onset while the inflammations initiating in brain tissue. This study employs Experimental Autoimmune Encephalomyelitis (EAE) models to show evidence that dexamethasone, a corticosteroid, restore the neurovascular units, also called blood-brain barrier (BBB), in spine cord through neovascularization. We discuss that pericytes are the key for neovascularization. In conclusion, application of hormone induces neovascularization in damaged centre nerve system tissue, has potential to establish effective lateral circulation after brain injury, including but not limited in stroke.
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