Abstract
Intracerebroventricular (ICV) microinfusion of recombinant human interleukin-1β (rhIL-1β, 0.125 to 2.0 ng/rat) dose-dependently suppressed 2 h and nighttime food intake in rats. The following daytime food intake did not change or increased. ICV infusion of bovine serum albumin (BSA), or heat-treated rhIL-1β had no effect on food intake. Pretreatment with dexamethasone (200 μg/rat, intraperitoneal) blocked the food intake suppression induced by low doses of rhIL-1β. This ability of dexamethasone, a synthetic corticosteroid, may have potential therapeutic implications in acute and chronic pathological processes associated with increased levels of IL-1 and appetite suppression.
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