Abstract
The hexamethylene bisacetamide(HMBA) induced differentiation of murine erythroleukemia cells is inhibited by dexamethasone (DEX). We show here that addition of hemin (100 pM) to cells cultured with HMBA (4mM) and DEX (100 μM) leads to an appearance of hemoglobin containing cells. However these cells cultured with HMBA, DEX, and hemin are not reprogrammed to limited growth. DEX does not inhibit the synthesis of the nuclear protein IP25. Hence commitment to terminal differentiation is controlled by at least one heme-independant event (other than the induction of IP25) which is inhibited by DEX.
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