Abstract
Bacterial conjunctivitis represents the major part of infectious conjunctivitis and, although it generally shows a spontaneous resolution, antibiotics speed the elimination of bacteria from the conjunctiva thus limiting the duration of the disease. The addition of anti-inflammatory drugs may potentiate the effectiveness of antibiotics in eradicating bacterial conjunctivitis. Aim of the present study is to compare the efficacy of two different eye drops based on ofloxacin without or with dexamethasone against bacterial conjunctivitis induced by <i>Staphylococcus aureus</i> or Pseudomonas aeruginosa.
Highlights
The conjunctiva is a highly vascularized and innervated layer of mucosal tissue playing an important role in eye lubrication and protection through the production of mucus and tears, and the prevention of microbial entrance [1]
Aim of the present study is to compare the efficacy of two different eye drops based on ofloxacin without or with dexamethasone against bacterial conjunctivitis induced by Staphylococcus aureus or Pseudomonas aeruginosa
The effectiveness of two different ofloxacin-based eye drops, formulated without or with dexamethasone, was investigated in rabbit models of bacterial conjunctivitis induced by either S. aureus or P. aeruginosa
Summary
The conjunctiva is a highly vascularized and innervated layer of mucosal tissue playing an important role in eye lubrication and protection through the production of mucus and tears, and the prevention of microbial entrance [1]. Staphylococcus aureus is a Gram-positive organism mainly involved in acute conjunctivitis, Pseudomonas aeruginosa, a Gram-negative bacterium, may be responsible for acute forms of the disease [3]. Acute bacterial conjunctivitis is a self-limiting disease, with spontaneous resolution within 7-10 days after infection, in some cases the disease may go on to become chronic [7]. Bacterial conjunctivitis represents the major part of infectious conjunctivitis and, it generally shows a spontaneous resolution, antibiotics speed the elimination of bacteria from the conjunctiva limiting the duration of the disease. Aim of the present study is to compare the efficacy of two different eye drops based on ofloxacin without or with dexamethasone against bacterial conjunctivitis induced by Staphylococcus aureus or Pseudomonas aeruginosa
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