Abstract
Passage of dexamethasone from plasma to milk in five lactating dairy cows after an intravenous injection was evaluated by a high performance liquid chromatographic technique for measurement of concentrations in blood plasma and milk. The dexamethasone ester was 21-iso-nicotinate as a solution and was administered at .1 mg/kg body weight. The drug was detected in milk postinjection from 15min to 8h with a peak concentration of 20.6ng/ml at the second sample time (30min). Half-times of dexamethasone in plasma and milk were 4.5 and 3.0h. The ratio of mean concentration for milk/plasma was .39. It is anticipated that no residues of dexamethasone would be detected in milk if normal dairy practices are followed.
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