“Dew-of-Leaf” structure multiple synergetic antimicrobial modality hybrid: A rapid and long lasting bactericidal material

Abstract

• Ag-PCN@Ti 3 C 2 -BC was fabricated achieving MSAM hybrid material. • A Rapid and long lasting antibacterial hybrid material was provided. • Rapid antibacterial effect was achieved by photodynamic and photothermal effect. • Long lasting antibacterial effect was achieved by Ag + ions releasing. • 1 O 2 and heat pushed the Ag + ions releasing from the sputtered silver under light illumination. Multiple synergetic antimicrobial modality (MSAM) platform is a novel approach which has highly advocated recently to meet the challenge of bacterial infection. In this research, we constructed a “Dew-of-Leaf” like hybrid material (Ag-PCN@Ti 3 C 2 -BC) with multiple design features that integrated photodynamic, photothermal and silver ion releasing effects. Porphyrinic MOFs (PCN-224) grown on Ti 3 C 2 nanosheets was first filtered onto BC, then nanosilver was sputtered using magnetron sputtering technique. Interestingly, the light-driven singlet oxygen produced by PCN-224 and the heat produced by Ti 3 C 2 not only synergistically enhanced the antibacterial effect, but also promoted the sputtered nanosilver to be degraded to release silver ions, achieving rapid bacterial inactivation and long lasting bacterial inhibition effects. Moreover, after two rounds of bacterial inactivation and 6 months of room environment preservation, an antibacterial inactivation study still demonstrated 99.9999% elimination of Gram-negative Escherichia coli ATCC-8099 and Gram-positive Staphylococcus aureus ATCC-6538 with Ag-PCN@Ti 3 C 2 -BC. Taken together, this nanofiber hybrid material permits an effective way to inactivate bacteria rapidly at first and long lasting bacterial inhibition followed, showing great potential for microbial disinfection.