Developments in the Synthesis of Organometallic Amino Acids and Analogues

Abstract

Structure and function of synthetic amino acids with side chain metal complexes have particular importance for extending our understanding of organometallic compounds under physiological conditions and mimic protein folding and stabilization. Chemists are now designing biomimetic organo-metallic amino acids that can form both secondary and tertiary structures. An overview of the design and synthesis of non-proteinogenic amino acids containing metal ions in the side chain is discussed. Keywords: Amino acid analogues, side chain metal complex, synthesis, structure