Abstract
Other methods for improving radiotherapy that are under active development include non-standard fractionation, better physical depth dose distributions using low-LET beams, hypertbermia or chemotherapy as adjuncts, and several methods of eliminating hypoxic cells, of which the electron-affinic radiosensitizers are the most promising at present. Several fractions of radiation each day appear to be giving interesting clinical results in several institutes. High-LET radiation plus radiosensitizers gives more therapeutic gain in animal experiments than either alone; provided that there is a wide spread of LET as in the case of fast neutron or pion beams. High-LET radiation plus protons may provide good physical distributions together with elimination of hypoxic cells. All three methods—high-LET, non-standard fractionation and bypoxic-cell radiosensitizers, may enable shorter radiotherapy schedules to be used more reliably. The cost implications are obvious.
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