Developmentally important genes in have larger intergenic intervals than their counterparts

Abstract

Copyright information: Taken from regulatory content of intergenic DNA shapes genome architectureGenome Biology 2004;5(4):R25-R25.Published online 15 Mar 2004http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395784/Copyright © 2004 Nelson et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Forty-nine developmentally important genes from and their counterparts. Genes in the top section represent orthologs, defined by KOG. Subsequent sections represent gene families. Listing of genes in different species on the same line within gene families does not imply that they are orthologous. The mean intergenic size for the genes is 27,928 bp. Then mean intergenic size for the genes is 7,670 bp. Genomic regions of four representative gene sets in (red) and (blue). Orange boxes designate exons of the indicated genes. Gray boxes designate exons of neighboring genes. Note that genomic intervals are typically larger in than in , often owing to both larger flanking noncoding regions and larger introns. The total euchromatic genome of is estimated at 117 Mb and the euchromatic genome of is estimated at 100 Mb. The overall gene distribution within the genome is denser in flies than worms, suggesting that the larger regions of noncoding DNA associated with these representative complex genes are specifically allocated to these loci.