Abstract
The postnatal development of [ 3H]thienylphencyclidine ([ 3H]TCP) sites in rat hippocampus has been studied autoradiographically and with membrane preparations. [ 3H]TCP binding increased progressively from birth to adulthood; this is due to a change in the maximal number of sites ( B max) but not in the affinity ( K a). A different developmental pattern was found for strychnine-insensitive [ 3H]glycine binding which also increased after birth, but reached adult levels earlier than [ 3H]TCP binding. The ontogenesis of TCP or glycine sites also differed from that previously described for N- methyl- d-aspartate (NMDA) sites in the hippocampus. In neonatal, as in adult hippocampus, [ 3H]TCP binding was enhanced by NMDA or glycine and reduced by Mg 2+. We suggest that TCP sites are functionally coupled to the NMDA receptor-ion channel complex in developing as in mature hippocampus, but that there are developmental changes in the receptor channel complex.
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