Abstract
BackgroundIn IVF-ICSI cycles with single embryo transfer (SET), embryo selection for transfer is of crucial importance. The present study aimed to define which embryo parameters might be related to the implantation potential of advanced blastocysts.MethodsOverall, in 203 cycles with SET, developmental characteristics of 93 implanted (group A) and 110 non-implanted (group B) advanced blastocysts of good quality were compared. The following developmental parameters were assessed in the two groups: normal fertilization, developmental stage on day 5, number of blastomeres on day 2 and on day 3, fragmentation rate on day 3, compaction on day 4 and cleavage pattern on day 2 and day 3.ResultsExpanded blastocysts compared to full blastocysts have higher implantation potential (56.5% vs. 29.3%, p < 0.05). In group B, a higher proportion of advanced blastocysts showed between 10% and 50% anucleated fragments on day 3 than in group A (23.6 vs 11.8, P = 0.03). Advanced blastocysts with >10–50% fragments on day 3 showed a significant lower implantation (29.7%) than those with ≤ 10%fragments (49.4%, P = 0.03). All the other parameters analysed were comparable for the two groups.ConclusionDevelopmental stage on day 5 and fragmentation rate on day 3 were related to the implantation potential of advanced blastocysts and should also be taken into account in the selection of the best advanced blastocyst for transfer.
Highlights
In IVF-ICSI cycles with single embryo transfer (SET), embryo selection for transfer is of crucial importance
Growing concerns have been raised regarding the risks of multiple pregnancies which consist of approximately 30% of the deliveries after assisted reproductive technology (ART) [1]
Van Royen et al reported an interesting approach, in which they estimated the implantation potential of day 3 embryos, comparing all the embryos leading to an ongoing implantation to those that did not result in a pregnancy [12]
Summary
In IVF-ICSI cycles with single embryo transfer (SET), embryo selection for transfer is of crucial importance. Either on day 2 [4,5,6,7,8,9] have attempted to quantify the implantation potential of an embryo by means of scoring systems based on different embryological parameters such as blastomere size, cell number, cleavage speed, degree of fragmentation. These factors have been combined in a variety of different ways to yield embryo-scoring systems that could predict pregnancy [10,11]. Van Royen et al reported an interesting approach, in which they estimated the implantation potential of day 3 embryos, comparing all the embryos leading to an ongoing implantation to those that did not result in a pregnancy [12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
