Abstract
Introduction. Axial flow pumps are being developed and applied for left ventricular assistance. We are studying a new, smaller and more energy efficient axial flow pump that could improve the current technology of left ventricular assistance. Method. A new axial flow pump was implanted through canulation of the left ventricular apex and the descending thoracic aorta of 3 pigs. The flow pump was set at 10,000 rpm and systemic blood samples from the animals were harvested every 30 minutes for analysis of the free hemoglobin. Results. Systemic blood pressure averaged 67±4 mmHg throughout the experiment. Plasma free hemoglobin levels averaged 42±9g/L before initiation of support with the axial flow pump and 43±11, 45±21, 68 46, 70±1, 105±45 and 127±35 dl respectively 30, 60, 90, 120, 150 and 180 minutes during left ventricular support with the axial flow pump at 10,000 rpm. After 4 hours of left ventricular support, an autopsy of the pig heart showed a clear left ventricular cavity without any formation of thrombus. Conclusion. Our preliminary experience with a new design of axial flow pump suggests that the blood pump does not create a significant degree of hemolysis during a short period of left ventricular support. The long-term effect of the new axial flow pump needs to be studied.
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