Abstract
Rats were housed under a 12-hr light (07:00-19:00)/12-hr dark cycle. Hepatic 3-hydroxy-3-methyglutaryl coenzyme A reductase mRNA appeared at 3 weeks of age, and diurnal variation was established at 5 weeks of age. Diurnal variation of the D-Site binding protein (DBP) mRNA was faintly seen 1 week after birth and became evident with age. Serine dehydratase mRNA level was high at 11:00 in the livers of rats at 2–3 days of age, and at 15:00 in those at 1–2 weeks of age. The rhythm became ambiguous at 3–4 weeks of age, but an adult-type rhythm with a peak at 19:00 was established at 5 weeks of age.
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