Abstract
Top of pageAbstract Altogether 58 infants who weighed between 600 and 1600 grams (mean 1035 grams) at birth were enrolled in randomized trials of surfactant supplementation in the University Central Hospital, Helsinki. There were 31 surfactant treated infants of whom 8 died during neonatal period and 28 placebo treated ones, of whom 16 died. The surviving infants were followed up prospectively for neurodevelopmental outcome as described previously (Duodeclm 98:848, 1982). The follow-up team was not aware of the treatment allocation. The mean follow-up time was 20 months (range 9 to 27 months). The results of the neurodevelopmental outcome were classified as: 1. normal, 2. possibly normal, 3. minor abnormality, 4. major abnormality. Group A had no serious infections in infancy, group B had recurrent hospitalization due to infections and chronic lung disease. The results were as follows: Surfactant substitution did not result in increased survival of “abnormal” small preterm infants. The study continues.
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