Abstract
Investigators at the National Center of Neurology and Psychiatry, Tokyo, studied the effect of early hemispherectomy on development in a consecutive series of 12 infants with hemimegalencephaly (HME) and epileptic encephalopathy.
Highlights
Investigators at Children’s Memorial Health Institute, Warsaw, Poland, report monozygotic twin sisters with tuberous sclerosis complex (TSC), one treated with the mTOR inhibitor everolimus since age 4 years
Eleven patients had a history of early infantile epileptic encephalopathy
8 (66.7%) were seizure-free and showed significantly higher postoperative developmental quotient (DQ) than those with seizures
Summary
Investigators at Children’s Memorial Health Institute, Warsaw, Poland, report monozygotic twin sisters with tuberous sclerosis complex (TSC), one treated with the mTOR inhibitor everolimus since age 4 years. Investigators at the National Center of Neurology and Psychiatry, Tokyo, studied the effect of early hemispherectomy on development in a consecutive series of 12 infants with hemimegalencephaly (HME) and epileptic encephalopathy. Mean age at onset was 20.4 days, mean age at surgery was 4.3 months (range 2-9), and mean follow-up time was 78.8 months (36-121).
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