Developmental mechanism of splenomegaly and portal hypertension in non-cirrhotic peri-portal fibrosis with splenomegaly (so-called Banti’s syndrome)

Abstract

The results of authors’ studies on the mechanisms of development of splenomegaly and portal hypertension in non-cirrhotic peri-portal fibrosis with splenomegaly (so-called Banti’s syndrome) were described in this report. The authors are of the opinion that, in this disorder, typical splenomegaly with hyperplasia of pulp cord and of sinus can be developed by the intervention of high portal pressure into the preliminary change in the spleen which is considered to be splenitic reaction mainly characterized by hyperplasia of pulp cord, and that the two factors of the increased splenic blood flow and the obliteration of intrahepatic portal branches would serve as the key factors to elevate the portal pressure. Studies on the mesenteric blood flow in portal hypertension revealed that the portal pressure after splenectomy is not only influenced by the disappearance of the splenic blood flow but also by the increase in the mesenteric blood flow.