Abstract
Fetal hematopoiesis can be distinguished from adult hematopoiesis by the differential generation of certain innate-like lymphocytes. Whether differential lymphoid output arises as a consequence of developmentally restricted hematopoietic stem cell (HSC) populations or whether their generation is limited by a fetal-specific microenvironment, or both, remains to be established. We investigated the mechanisms underlying differential immune cell production during development using a recently established lineage tracing mouse model wherein Flk2-driven expression of Cre recombinase results in the irreversible switching of a dual-color reporter from Tomato to GFP expression.
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