Abstract
Publisher Summary Erythropoiesis in the normal fetal mouse occurs first in the yolk sac blood islands beginning at around day 8 of gestation. These erythroid cells are subsequently released into the circulation where they proliferate and mature in a relatively synchronized manner. These circulating primitive nucleated erythrocytes synthesize three embryonic hemoglobins, EI (X2Y2), EII (α2Y2), and EIII (α2Z2). The second site of erythropoiesis occurs in the fetal liver shortly after day 10 of gestation. The fetal hepatic erythroblasts proliferate and differentiate within the hepatic parenchyma and are released into the circulation as non-nucleated reticulocytes beginning at around day 12 of gestation. These definitive erythrocytes contain adult hemoglobin, α2β2. Some of the experiments indicate that the primitive erythroid cell line of yolk sac blood island origin produce embryonic hemoglobins early in gestation but later in gestation, these erythroid cells are also capable of producing adult hemoglobins in addition to embryonic hemoglobins. The in vitro culture experiments indicate that there are hemopoietic stem cells in circulation at a time when the fetal liver is not yet formed.
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