Abstract
The term “developmental haemostasis” was first coined by Maureen Andrews to describe the age-related physiological changes of the coagulation system during childhood.[1] Given the age-dependent specificity of haemostasis, the evaluation and the interpretation of coagulation assays in newborns may present diagnostic difficulties and appropriate reference ranges for the diagnosis and management of coagulopathies in moderate and late preterm infants are needed.
Highlights
The term “developmental haemostasis” was first coined by Maureen Andrews to describe the age-related physiological changes of the coagulation system during childhood.[1]
FV, FVIII, FXIII and von Willebrand are not decreased at birth.[2]
Plasma concentrations of antithrombin, protein C and protein S are low at birth, and they reach adult levels at about 612 months of life.[2]
Summary
The term “developmental haemostasis” was first coined by Maureen Andrews to describe the age-related physiological changes of the coagulation system during childhood.[1]. Age-related changes in the coagulation plasma proteins The haemostatic system is a dynamic evolving process that is age-dependent. Plasma concentrations of vitamin K-dependent and contact factors (F) are decreased if compared with adult levels.[2] During the first 6 months of life, they gradually increase to values approaching adult levels.[2] These changes in protein levels lead to corresponding changes in global tests of coagulation such as the Prothrombine Time and the Activated Partial Thromboplastin Time.
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