Abstract
The effects of mercury (Hg) on social behavior and the mechanisms involved remain unknown. This study shows that Hg chloride (HgCl2) exposure during fetal development does not impair social behavior of a mouse strain susceptible to environment-induced autistic-like behavior based on the parental phenotype. On the contrary, Hg exposure elevated the sociability of females. Since B6 mice are behaviorally normal and BTBR mice display low levels of sociability, the F1 offspring (B6BF1) of female B6 mice and male BTBR mice were used to investigate their social behavior and the effects of Hg. Developmental Hg-treatment increased the serum IgG levels of the post-natal day (pnd) 21 offspring, but not pnd70 offspring or the B6 dams. After Hg treatment, there were negligible levels of serum IgG anti-brain antibodies (Ab) in the pnd21 and pnd70 offspring as well as their dams. However, Hg did elevate IgG deposition in multiple assayed brain regions of the pnd21 offspring, but the higher levels were no longer present at pnd70. Cytokine levels were not changed in pnd21 or pnd70 brain by Hg exposure, suggesting neuroinflammation was not induced. Social behavior was assayed at pnd70. Surprisingly, Hg-treatment significantly enhanced sociability of female B6BF1 offspring, but not that of the male offspring. Our data indicates that developmental exposure to HgCl2 did not impair social behavior of B6BF1 offspring, but it enhanced the sociability of females, which was significantly lower in adult B6BF1 females than B6BF1 males in the absence of any Hg exposure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.